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The evidence

Same family of conditions. Not the same attention.

Two questions, asked the same way of all five conditions. How much has been written about each one? And how long does it take a person to get the name?

How much has been written

Our searches returned 9,296 achalasia records indexed in PubMed, 2,891 of them from before 1990. The modern-name R-CPD search returned 89 records. It misses earlier reports published under different names. These are search results, not a complete census of research.

05010015020025030035019901995200020052010201520202025R-CPD named, 2019AchalasiaZenker'sSpasmA-CPDR-CPD2026 so far

Achalasia: 269

Zenker's: 88

Spasm: 117

A-CPD: 28

R-CPD: 28

PubMed-indexed records returned by the stated Europe PMC searches on 2026-10-08. The 2026 line is dashed because the year is not over. On a phone, scroll the chart sideways or use the year selector.
Read all yearly values in a table
Records returned by year
YearAchalasiaZenker'sSpasmA-CPDR-CPD
1990106179100
1991110111430
199290291890
199394151720
199410230740
199511121950
1996107231160
1997120211150
1998101281070
1999123311140
200011228980
2001130261080
200212232740
2003102331060
2004104241160
2005123281490
2006133291220
2007114381770
20081302830100
2009139391790
2010145391770
20111443623100
2012173363980
20132185840150
20141706041120
20152535267130
20162586956150
20172326077230
20182395178150
20192216655241
20202967587252
202134382100123
20223187589255
20233449389303
202430164832620
2025269881172828
2026 (partial)20567623427
R-CPD on its own scale, 2015 to 2026
2015: 0 papers020152016: 0 papers0'162017: 0 papers0'172018: 0 papers0'182019: 1 paper1'192020: 2 papers220202021: 3 papers3'212022: 5 papers5'222023: 3 papers3'232024: 20 papers20'242025: 28 papers2820252026: 27 papers so far27'26
Papers per condition
ConditionAll timeBefore 19901990 to 2026Unreconciled difference
Achalasia9,2962,8916,4023
Zenker's1,8882851,6021
Spasm1,5371621,3741
A-CPD509634460
R-CPD890890

The final column makes differences between the all-time query and summed yearly queries explicit. The cause has not been verified; it may involve date indexing or records changing between requests. These differences are not assigned to a year.

How long it takes to get the name

Our search found dedicated diagnostic-delay studies for achalasia. For the other four, available figures came from small studies with other purposes, or for R-CPD, one clinic’s averages. Where nobody has measured something, the gap is left empty. “Not measured” here means no dedicated study was found in this search.

R-CPD

About 17 years

Symptoms began at a mean age of 13.6 and diagnosis came at a mean age of 30.4, in one clinic series of 106 patients.

No dedicated study found in our search

  • 13.6 vs 30.4 years

    Mean age at first symptoms vs at diagnosis

    Prospective clinic series, France, 106 people. Mailly 2025

    Two group averages, not each person's own wait. Patients who reach a specialist clinic may have waited longer than most.

  • 99.1%

    Worked out the diagnosis themselves

    Prospective clinic series, France, 106 people. Mailly 2025

    After a combined 162 medical visits.

  • 78.9%

    Recognised the diagnosis themselves

    5 studies that recorded how the diagnosis was made, within a systematic review, 450 people. Lechien 2025

    About 450 patients in those 5 studies. Pooled from uncontrolled studies.

  • All 13

    First learned the name on social media

    Qualitative interview study, United States, 13 people. Miller 2024

    Small and not designed to give a percentage, but unanimous.

  • 32%

    A doctor put the symptoms down to reflux

    Online survey of an R-CPD community, 207 people. Chen 2026

    Self-reported, recruited online.

  • 28%

    Given a different diagnosis before seeing a specialist (children)

    Retrospective chart review, 25 people. Wright 2026

    Small and from one centre.

A-CPD

Not measured

No study in the search measured how long it takes to diagnose. The only figure is a symptom duration from a 1980 surgical series.

No dedicated study found in our search

  • 3.9 years (range 1 month to 11 years)

    Average symptom duration before surgery

    Surgical case series, 1980, 40 people. Orringer 1980

    Written before modern definitions. 30% of these patients also had a Zenker's pouch.

Achalasia

About 2 years

Median 24 months in a recent Italian study of 278 patients. Our search found six studies of diagnostic delay in adults and children.

6 studies built to measure it

  • 24 months (IQR 12 to 72)

    Median time to diagnosis

    Retrospective single-centre study, Italy, 2013 to 2023, 278 people. Pasta 2024

    76.6% waited more than a year.

  • 4.7 years

    Mean time to diagnosis

    Retrospective database, Germany, 30 years, 300 people. Müller 2023

    42% had at least one wrong diagnosis first (26% one, 16% more than one), most often reflux (16.7%).

  • 5.7 years

    Mean time to diagnosis

    Consecutive patients, France, 1980 to 1998, 345 people. d'Alteroche 2001

    Older data; no shortening over the period studied.

  • 4.7 years

    Mean symptom duration before diagnosis

    Prospective structured interviews, Germany, 87 people. Eckardt 1997

    Longer waits went with more unsuccessful doctor visits, not with unusual symptoms.

  • 22 months

    Mean time to diagnosis (children)

    Retrospective single-centre study, Iran, 100 people. Mazhari 2025

    Standard deviation 33 months, so a wide spread.

  • 10.5 months

    Median time to diagnosis (children)

    Retrospective multicentre study, France, 97 people. Nicolas 2022

Zenker's

Not measured

Only one small study (28 patients) reports a delay before diagnosis. Other small treatment series give how long symptoms had lasted.

No dedicated study found in our search

  • 4.8 years

    Mean symptom duration

    Case series of a new endoscopic technique, 7 people. Tang 2008

    Seven patients.

  • 17 months

    Delay before diagnosis

    Retrospective series, France, 28 people. Merrot 2003

    Elderly patients treated with laser.

  • 2.5 years

    Mean symptom duration

    Prospective treatment series, 25 people. Maydeo 2019

    Includes 5 patients with a different kind of pouch.

Spasm

Not measured

No study in the search measured diagnostic delay. One small POEM series mentions symptom duration.

No dedicated study found in our search

  • 42.6 months

    Mean symptom duration before POEM

    Retrospective single-centre series, jackhammer esophagus, 13 people. Canakis 2023

    Thirteen patients, measured at treatment rather than diagnosis.

What was counted, and what was thrown out

Paper counts come from the Europe PMC search service, one search per condition per year, counting only papers indexed in PubMed. They were collected on 8 October 2026. The exact searches are listed below so anyone can repeat them.

The first R-CPD count was wrong. The original search included the bare abbreviation “R-CPD” and found 144 papers from 1990 on. Reading them showed that many had nothing to do with swallowing. Chemists use R-CPD for other things, including a kind of fluorescent particle, and 17 of those papers were from before the condition was even named. Conference abstract books also matched. Dropping the bare abbreviation and keeping only PubMed papers left 89, all from 2019 on.

A-CPD and R-CPD overlap. The phrase “cricopharyngeal dysfunction” also appears in every paper about retrograde cricopharyngeal dysfunction, so the A-CPD search excludes those papers to avoid counting them twice. It still includes papers about swallowing problems after strokes and other nerve conditions, which use the same words.

Diagnosis times were read by hand. Europe PMC was searched for each condition together with “diagnostic delay”, “time to diagnosis”, “misdiagnosis” or “misdiagnosed”. That returned 389 different PubMed papers, most of them single case reports. Every abstract with a number near those words was checked in the original research pass. The diagnostic-delay review is separate from the refreshed paper counts; it is not a systematic review. Each displayed estimate links to its source.

The refreshed spasm search includes “distal esophageal spasm” and “hypercontractile esophagus”. R-CPD counts remain restricted to modern names: older inability-to-belch reports exist, including reports from 1987, 1989 and 2001 discussed in Lechien and colleagues’ review. Adding broad inability-to-belch terms also finds postoperative problems unrelated to R-CPD, so those results are not presented as R-CPD research. No records under the modern name before 2019 does not mean no earlier research.

Searches used for this snapshot

Achalasia
("esophageal achalasia" OR "achalasia cardia") AND SRC:MED
Zenker's
("Zenker diverticulum" OR "Zenker's diverticulum") AND SRC:MED
Spasm
("diffuse esophageal spasm" OR "distal esophageal spasm" OR "jackhammer esophagus" OR "hypercontractile esophagus") AND SRC:MED
A-CPD
("cricopharyngeal achalasia" OR "antegrade cricopharyngeal" OR "cricopharyngeal dysfunction") NOT ("retrograde cricopharyngeus" OR "retrograde cricopharyngeal") AND SRC:MED
R-CPD
("retrograde cricopharyngeus" OR "retrograde cricopharyngeal") AND SRC:MED

What not to read into this

  • A paper count measures attention, not quality. Thousands of achalasia papers include many single case reports. R-CPD’s 89 include meta-analyses. The comparison is sensitive to terminology, indexing and search coverage. It cannot by itself measure research quality or clinical attention.
  • The R-CPD 17 years is two averages, not a measured wait. It is the gap between the average age when symptoms began and the average age at diagnosis in one French clinic. People who reach a specialist clinic may have waited longer than most.
  • The achalasia studies disagree. The median wait was 24 months in Italy and the mean was 4.7 years in Germany. These studies involved different patients and methods, so the results are not directly comparable. A mean is more affected by unusually long waits than a median.
  • 2026 is not finished. The last point on the chart covers part of the year.