Recruiting trials

Studies to keep an eye on

33 studies on ClinicalTrials.gov are listed as recruiting or not yet recruiting for people with one of these five conditions. These are the studies our search found. Registry summaries may use medical terms. A registry listing does not guarantee an open place. Checked 8 October 2026.

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Zenker's

5 studies · About Zenker's

RecruitingFollows people, no new treatmentAlso A-CPD
Follows people treated for a Zenker's pouch or a tight cricopharyngeus, either through the neck or through the mouth, including people who are not having surgery.
Cricopharyngeal Dysfunction and Esophageal Diverticulum
Where
Cincinnati, Ohio, United States
Who
Ages 18 to 100, about 500 people
Run by
University of Cincinnati
NCT03187925 on ClinicalTrials.gov
Registry last updated: 2023-09-13. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
Records how people do after a flexible endoscopic cut of the wall between a Zenker's pouch and the esophagus.
Endoscopic Treatment for Zenker's Diverticulum
Where
Rozzano, Italy
Who
Ages 18 and over, about 400 people
Run by
Istituto Clinico Humanitas
NCT03948438 on ClinicalTrials.gov
Registry last updated: 2022-09-21. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
A registry of advanced endoscopic procedures at one Montreal hospital, including treatment of Zenker's pouches.
Advanced Endo-therapeutic Procedure : Registry-based Observational Study
Where
Montreal, Canada
Who
Ages 18 and over, about 500 people
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
NCT04117100 on ClinicalTrials.gov
Registry last updated: 2026-08-11. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatmentAlso AchalasiaAlso Spasm
Records outcomes for everyone treated with POEM at one Orlando hospital, including achalasia, spasm and Zenker's.
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Where
Orlando, Florida, United States
Who
Ages 18 and over, about 600 people
Run by
AdventHealth
NCT05905016 on ClinicalTrials.gov
Registry last updated: 2026-02-02. A recent check does not mean the study team recently updated its record.
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Not yet recruitingFollows people, no new treatment
Compares Z-POEM with other endoscopic treatments for Zenker's pouches across French centres, looking at how often symptoms come back after a year.
Endoscopic Treatment of Zenker's Diverticulum (ZENKTUN)
Where
Sites not listed yet
Who
Ages 18 to 90, about 128 people
Run by
Société Française d'Endoscopie Digestive
NCT06594718 on ClinicalTrials.gov
Registry last updated: 2024-09-19. A recent check does not mean the study team recently updated its record.
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R-CPD

No studies · About R-CPD

No open studies found in this search.

No studies for R-CPD match this view, checked on 8 October 2026. Try clearing filters. Studies in other registries or under other terms may not appear here.

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A-CPD

2 studies · About A-CPD

RecruitingFollows people, no new treatmentAlso Zenker's
Follows people treated for a Zenker's pouch or a tight cricopharyngeus, either through the neck or through the mouth, including people who are not having surgery.
Cricopharyngeal Dysfunction and Esophageal Diverticulum
Where
Cincinnati, Ohio, United States
Who
Ages 18 to 100, about 500 people
Run by
University of Cincinnati
NCT03187925 on ClinicalTrials.gov
Registry last updated: 2023-09-13. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Tests Botox injected into the upper sphincter against a placebo for swallowing trouble caused by a tight cricopharyngeus, mostly after stroke and other nerve conditions.
Onabotulinum Toxin A (Botox) in the Treatment of Pharyngo-esophageal Dysphagia
Where
New Delhi, India
Who
Ages 14 and over, about 100 people
Run by
All India Institute of Medical Sciences
NCT04695600 on ClinicalTrials.gov
Registry last updated: 2026-07-07. A recent check does not mean the study team recently updated its record.
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Spasm

3 studies · About Spasm

RecruitingFollows people, no new treatmentAlso AchalasiaAlso Zenker's
Records outcomes for everyone treated with POEM at one Orlando hospital, including achalasia, spasm and Zenker's.
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Where
Orlando, Florida, United States
Who
Ages 18 and over, about 600 people
Run by
AdventHealth
NCT05905016 on ClinicalTrials.gov
Registry last updated: 2026-02-02. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatmentAlso Achalasia
A US study following people with type III achalasia, jackhammer esophagus and related spastic problems, to see whether testing before POEM helps doctors choose how long to cut.
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
Where
Scottsdale, Arizona, United States; La Jolla, California, United States; Denver, Colorado, United States; and 13 more
Who
Ages 18 and over, about 200 people
Run by
Northwestern University
NCT07293689 on ClinicalTrials.gov
Registry last updated: 2026-08-28. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedureAlso Achalasia
Compares two ways of making the first opening in the lining during POEM.
Transverse vs Longitudinal Mucosal Incision During POEM
Where
Bogotá, Colombia
Who
Ages 18 and over, about 140 people
Run by
Universidad Nacional de Colombia
NCT07425977 on ClinicalTrials.gov
Registry last updated: 2026-02-24. A recent check does not mean the study team recently updated its record.
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Achalasia

28 studies · About Achalasia

RecruitingTests a treatment or procedure
Follows people with achalasia and related problems treated with POEM, prolonged balloon dilation or keyhole surgery, to compare how each works.
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia
Where
Vienna, Austria
Who
Ages 18 and over, about 400 people
Run by
Medical University of Vienna
NCT02518542 on ClinicalTrials.gov
Registry last updated: 2015-08-10. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
A registry of people with achalasia treated with POEM at one Dallas hospital.
Peroral Endoscopic Myotomy for the Treatment of Achalasia
Where
Dallas, Texas, United States
Who
Ages 18 and over, about 200 people
Run by
Methodist Health System
NCT04640753 on ClinicalTrials.gov
Registry last updated: 2026-06-10. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Takes small muscle samples and FLIP measurements in people with achalasia and related problems, to see how scarring in the muscle relates to how the sphincter behaves.
Comprehensive Esophageal Diagnostics Study
Where
Atlanta, Georgia, United States; Atlanta, Georgia, United States
Who
Ages 18 and over, about 80 people
Run by
Emory University
NCT04641702 on ClinicalTrials.gov
Registry last updated: 2026-09-16. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Tests whether an antiviral drug and the shingles vaccine help people whose achalasia is linked to an ongoing chickenpox virus infection in the nerves of the esophagus.
VZV in the Enteric Nervous System: Pathogenesis and Consequences
Where
Nashville, Tennessee, United States
Who
Ages 18 to 75, about 40 people
Run by
Vanderbilt University Medical Center
NCT05550194 on ClinicalTrials.gov
Registry last updated: 2026-10-05. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Compares taking acid medicine every day after POEM with taking it only when symptoms appear, to see which better prevents reflux.
Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per Oral Endoscopic Myotomy for Esophageal Achalasia
Where
Marseille, France; Montpellier, France; Montpellier, France; and 1 more
Who
Ages 18 and over, about 132 people
Run by
Centre Hospitalier Universitaire de Nīmes
NCT05899842 on ClinicalTrials.gov
Registry last updated: 2026-02-10. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatmentAlso SpasmAlso Zenker's
Records outcomes for everyone treated with POEM at one Orlando hospital, including achalasia, spasm and Zenker's.
Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders
Where
Orlando, Florida, United States
Who
Ages 18 and over, about 600 people
Run by
AdventHealth
NCT05905016 on ClinicalTrials.gov
Registry last updated: 2026-02-02. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Tests magnetic stimulation of the brain, with no surgery, as a treatment for achalasia, against a sham version.
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
Where
Nanjing, China
Who
Ages 18 to 75, about 112 people
Run by
Zhang Nina
NCT06027190 on ClinicalTrials.gov
Registry last updated: 2023-09-21. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Compares standard POEM with POEM plus a wrap made from the inside, to see if the wrap reduces reflux afterwards.
POEM-F for Achalasia International Study
Where
Baltimore, Maryland, United States; Guangzhou, China; Hong Kong, Hong Kong; and 4 more
Who
Ages 18 to 65, about 81 people
Run by
Chinese University of Hong Kong
NCT06042127 on ClinicalTrials.gov
Registry last updated: 2024-12-03. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Compares two electrical settings used during POEM to see which is safer and quicker.
Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy
Where
Cairo, Egypt
Who
Ages 18 and over, about 52 people
Run by
Cairo University
NCT06189859 on ClinicalTrials.gov
Registry last updated: 2025-05-13. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
Compares a pressure-and-flow test with a timed barium X-ray for measuring how well the esophagus empties after achalasia treatment.
MARIMPACH : Contribution of High-resolution Manometry With Impedancemetry for the Evaluation of Esophageal Clearance in Achalasia
Where
Pessac, France
Who
Ages 18 and over, about 104 people
Run by
University Hospital, Bordeaux
NCT06230536 on ClinicalTrials.gov
Registry last updated: 2024-07-26. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
Looks at how poor nutrition affects breathing and kidney function during anesthesia for POEM.
Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)
Where
Istanbul, Turkey (Türkiye)
Who
Ages 18 to 80, about 60 people
Run by
Umraniye Education and Research Hospital
NCT06405412 on ClinicalTrials.gov
Registry last updated: 2025-11-19. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Compares a shorter, more targeted POEM cut with the standard cut in people with type II achalasia who have not been treated before.
Standard Versus Oesophago-gastric Junction Complex Myotomy for Treatment naïve Type 2 Achalasia Patients
Where
Hyderabad, India
Who
Ages 18 to 75, about 158 people
Run by
Asian Institute of Gastroenterology, India
NCT06870630 on ClinicalTrials.gov
Registry last updated: 2025-06-10. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Uses pressure tests, FLIP and a gut-motility drug to understand how the esophagus moves in people with swallowing trouble, including achalasia.
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Where
Chicago, Illinois, United States
Who
Ages 18 to 85, about 575 people
Run by
Northwestern University
NCT06883175 on ClinicalTrials.gov
Registry last updated: 2026-09-23. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Compares balloon dilation with POEM in children aged 3 to 17 with achalasia.
Comparison of Balloon Dilatation and Per Oral Endoscopic Myotomy in Children With Achalasia Cardia
Where
Sites not listed yet
Who
Ages 3 to 17, about 70 people
Run by
Asian Institute of Gastroenterology, India
NCT07167355 on ClinicalTrials.gov
Registry last updated: 2025-09-11. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Compares standard POEM with a version that spares some muscle fibres at the stomach, to see if it causes less reflux.
Sling-Fiber Preservation POEM vs. Conventional POEM for Reducing Post-POEM GERD
Where
Orange, California, United States
Who
Ages 18 and over, about 120 people
Run by
University of California, Irvine
NCT07178821 on ClinicalTrials.gov
Registry last updated: 2025-10-22. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
Tests whether a fluorescent dye during Heller myotomy helps surgeons spot small tears in the lining.
The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor
Where
Naples, Italy
Who
Ages 18 and over, about 70 people
Run by
Federico II University
NCT07181070 on ClinicalTrials.gov
Registry last updated: 2025-09-23. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Compares how POEM works in people with achalasia who have never been treated and people who have already had balloon dilation.
Comparative Study of Per-oral Endoscopic Myotomy (POEM) in Treatment - naïve Achalasia Patients Versus Patients With Previous Pneumatic Dilation
Where
Sites not listed yet
Who
Ages 18 and over, about 32 people
Run by
Assiut University
NCT07287787 on ClinicalTrials.gov
Registry last updated: 2025-12-17. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
A large US trial testing whether a shorter, tailored POEM cut works as well as the standard cut for achalasia types I and II, with less reflux.
PREcision MEDicine In Achalasia (PREMEDIA)
Where
Scottsdale, Arizona, United States; La Jolla, California, United States; Denver, Colorado, United States; and 13 more
Who
Ages 18 and over, about 372 people
Run by
Northwestern University
NCT07293650 on ClinicalTrials.gov
Registry last updated: 2026-08-28. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatmentAlso Spasm
A US study following people with type III achalasia, jackhammer esophagus and related spastic problems, to see whether testing before POEM helps doctors choose how long to cut.
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
Where
Scottsdale, Arizona, United States; La Jolla, California, United States; Denver, Colorado, United States; and 13 more
Who
Ages 18 and over, about 200 people
Run by
Northwestern University
NCT07293689 on ClinicalTrials.gov
Registry last updated: 2026-08-28. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Compares the standard POEM tunnel with two shorter versions in people with type II achalasia.
Comparison of Conventional and Short Submucosal Tunnel Techniques in Type II Achalasia
Where
Sites not listed yet
Who
Ages 19 to 75, about 636 people
Run by
Asian Institute of Gastroenterology, India
NCT07325071 on ClinicalTrials.gov
Registry last updated: 2026-01-08. A recent check does not mean the study team recently updated its record.
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Not yet recruitingFollows people, no new treatment
Measures metabolic changes, such as blood sugar and cholesterol, in people who regain weight after achalasia treatment.
Metabolic Changes Associated With Weight Gain After Treatment of Achalasia
Where
Jerusalem, Israel; Ẕerifin, Israel
Who
Ages 18 and over, about 30 people
Run by
Assaf-Harofeh Medical Center
NCT07334639 on ClinicalTrials.gov
Registry last updated: 2026-01-13. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Tests a new cutting device for POEM.
Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM
Where
Guayaquil, Ecuador; Hong Kong, Hong Kong
Who
Ages 18 and over, about 73 people
Run by
Chinese University of Hong Kong
NCT07406945 on ClinicalTrials.gov
Registry last updated: 2026-02-12. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedureAlso Spasm
Compares two ways of making the first opening in the lining during POEM.
Transverse vs Longitudinal Mucosal Incision During POEM
Where
Bogotá, Colombia
Who
Ages 18 and over, about 140 people
Run by
Universidad Nacional de Colombia
NCT07425977 on ClinicalTrials.gov
Registry last updated: 2026-02-24. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
Records outcomes of POEM done with a particular surgical device at one Houston hospital.
Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)
Where
Houston, Texas, United States
Who
Ages 18 and over, about 40 people
Run by
Baylor College of Medicine
NCT07496840 on ClinicalTrials.gov
Registry last updated: 2026-06-17. A recent check does not mean the study team recently updated its record.
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RecruitingFollows people, no new treatment
A large Italian registry of people having esophageal pressure tests, including people with achalasia.
PRospective Registry of Esophageal Motility
Where
Milan, Italy
Who
Ages 18 and over, about 10,000 people
Run by
IRCCS San Raffaele
NCT07506746 on ClinicalTrials.gov
Registry last updated: 2026-04-02. A recent check does not mean the study team recently updated its record.
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Not yet recruitingTests a treatment or procedure
Compares short and long tunnels during POEM in people with type II achalasia.
Short Versus Long Submucosal Tunneling in Per-oral Endoscopic Myotomy (POEM) for Type II Achalasia.
Where
Asyut, Egypt
Who
Age limits not specified, about 50 people
Run by
Assiut University
NCT07686471 on ClinicalTrials.gov
Registry last updated: 2026-07-07. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Checks whether lying on your back or your side changes FLIP measurements, in children and young adults aged 5 to 21.
Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions
Where
Baltimore, Maryland, United States
Who
Ages 5 to 21, about 25 people
Run by
Johns Hopkins University
NCT07780981 on ClinicalTrials.gov
Registry last updated: 2026-08-24. A recent check does not mean the study team recently updated its record.
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RecruitingTests a treatment or procedure
Compares POEM with Heller myotomy plus a Dor wrap for achalasia.
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia
Where
Minya, Egypt
Who
Ages 18 to 75, about 220 people
Run by
Minia University
NCT07814027 on ClinicalTrials.gov
Registry last updated: 2026-09-22. A recent check does not mean the study team recently updated its record.
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